hydroxocobalamin in a sentence

• Hydroxocobalamin, which has affinity for cyanide, picks it up and changes to cyanocobalamin.
• Sodium thiosulfate has been considered as an empirical treatment for cyanide poisoning, along with hydroxocobalamin.
• Hydroxocobalamin is sometimes denoted B 12a.
• Hydroxocobalamin has a higher affinity to the TC II transport protein than cyanocobalamin, or 5-deoxyadenosylcobalamin.
• Hydroxocobalamin has an avid affinity for cyanide ions and has been used as an antidote to cyanide poisoning.
• For cyanide poisoning, a large amount of hydroxocobalamin may be given intravenously and sometimes in combination with sodium thiosulfate.
• Cyanocobalamin is usually converted to hydroxocobalamin in the serum, whereas hydroxocobalamin is converted to either methylcobalamin or 5-deoxyadenosyl cobalamin.
• Cyanocobalamin is usually converted to hydroxocobalamin in the serum, whereas hydroxocobalamin is converted to either methylcobalamin or 5-deoxyadenosyl cobalamin.
• The vitamer is produced by bacteria as hydroxocobalamin, but conversion between different forms of the vitamin occurs in the body after consumption.
• In the United States, the Food and Drug Administration approved ( in 2006 ) the use of hydroxocobalamin for acute treatment of cyanide poisoning.
• It's difficult to see hydroxocobalamin in a sentence .
• These may be supplemented, although since cyanocobalamin contains the toxic chemical cyanide, dogs that have serious cobalamin issues should instead be treated with hydroxocobalamin or methylcobalamin.
• "' Hydroxocobalamin "'is another form of B 12 commonly encountered in pharmacology, but which is not normally present in the human body.
• Historically, a form of vitamin called hydroxocobalamin is often produced by bacteria and was then changed to cyanocobalamin during purification in activated charcoal columns after separation from the bacterial cultures.
• For most, the standard therapy for treatment of vitamin B 12 deficiency has been intramuscular ( IM ) injections in the form of cyanocobalamin ( CNCbl ) or hydroxocobalamin ( OHCbl ).
• Vitamin B12, in the form of hydroxocobalamin ( also spelled hydroxycobalamin ), may reduce the negative effects of chronic exposure, and a deficiency can lead to negative health effects following exposure.
• If the patient has inborn errors in the methyltransfer pathway ( cobalamin C disease, combined methylmalonic aciduria and homocystinuria ), treatment with intravenous, intramuscular hydroxocobalamin or transdermal B 12 is needed.
• This preference for hydroxocobalamin in many countries is due to its long retention in the body and the need for less-frequent IM injections in restoring vitamin B 12 ( cobalamin ) serum levels.
• In the serum, hydroxocobalamin and cyanocobalamin are believed to function as storage or transport forms of the molecule, whereas methylcobalamin and 5-deoxyadenosylcobalamin are the active forms of the coenzyme required for cell growth and replication.
• Furthermore, IM administration of hydroxocobalamin is also the preferred treatment for pediatric patients with intrinsic cobalamin metabolic diseases; vitamin B 12-deficient patients with tobacco amblyopia due to cyanide poisoning; and patients with pernicious anemia who have optic neuropathy.
• In a newly diagnosed vitamin B 12-deficient patient, normally defined as when serum levels are less than 200 pg / ml, daily IM injections of hydroxocobalamin up to 1, 000 ?g ( 1 mg ) per day are given to replenish the body s depleted cobalamin stores.