aminopterin in a sentence
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- Leucovorin has been used in rats, dogs and humans to rescue aminopterin toxicity.
- The selective culture medium is called HAT medium because it contains hypoxanthine, aminopterin and thymidine.
- This medium is supplemented with hypoxanthine, aminopterin and thymidine, hence the name HAT medium.
- Antimetabolite aminopterin blocks the cellular biosynthesis of purines and pyrimidines from simple sugars and amino acids.
- He believes those patients whose cancer cells are not absorbing the medicine may be candidates for aminopterin.
- Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.
- Aminopterin, a cytostatic drug with anti-folate effect, was used during the 1950s and 1960s to induce therapeutic abortions.
- The enzyme dihydrofolate reductase, which produces tetrahydrofolate ( THF ) by the reduction of dihydrofolate, is specifically blocked by aminopterin.
- By 1947 Boston pathologist Sidney Farber believed from past experiments that aminopterin, a folic acid mimic, could potentially cure leukemia in children.
- When a similar cluster of abnormalies appears in the absence of exposure to antifolates it is referred to as aminopterin-like syndrome without aminopterin.
- It's difficult to see aminopterin in a sentence .
- When a similar cluster of abnormalies appears in the absence of exposure to antifolates it is referred to as aminopterin-like syndrome without aminopterin.
- In contrast, animals given aminopterin in an amount of 0.041 mg / kg / day x 6 days without folic acid died.
- Similar congenital abnormalities have been documented with methotrexate, and collectively their teratogenic effects have become known as the " fetal aminopterin syndrome ".
- The use of aminopterin in cancer treatment was supplanted in the 1950s by methotrexate due to the latter's better therapeutic index in a rodent tumor model.
- Aminopterin is widely used in selection media ( such as HAT medium ) for cell culture, particularly in the development of hybridomas, which secrete monoclonal antibodies.
- This research subsequently led to the synthesis of the antifolate aminopterin, the first-ever anticancer drug, the clinical efficacy was proven by Sidney Farber in 1948.
- After fusion, the cells are grown in a medium with methotrexate or aminopterin that inhibit the enzyme dihydrofolate reductase thus blocking the de novo synthesis of thymidine monophosphate.
- As his condition improved, Pinkel began working with eminent researcher Sidney Farber in Boston, experimenting with aminopterin, which could induce temporary remissions in some leukemia cases.
- Fused cells are incubated in HAT medium ( hypoxanthine-aminopterin-thymidine medium ) for roughly 10 to 14 days . Aminopterin blocks the pathway that allows for nucleotide synthesis.
- Fused cells are incubated in HAT medium ( hypoxanthine-aminopterin-thymidine medium ) for roughly 10 to 14 days . Aminopterin blocks the pathway that allows for nucleotide synthesis.
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