oxaloacetates meaning

• Export of malate into the cytosol leads to formation of oxaloacetate, phosphoenol pyruvate, and other gluconeogenic intermediates.
• In 1937 German biochemists Franz Koop and Carl Martinus had demonstrated a series of reactions using citrate that produced oxaloacetate.
• Succinate-analogue inhibitors include the synthetic compound malonate as well as the TCA cycle intermediates, malate and oxaloacetate.
• High malate concentrations stimulate MDH activity, and, in a converse manner, high oxaloacetate concentrations inhibit the enzyme.
• Oxaloacetate is then transformed into aspartate ( since oxaloacetate cannot be transported into the cytosol ) by mitochondrial aspartate aminotransferase.
• Oxaloacetate is then transformed into aspartate ( since oxaloacetate cannot be transported into the cytosol ) by mitochondrial aspartate aminotransferase.
• The systematic name of this enzyme class is "'L-arogenate : oxaloacetate aminotransferase " '.
• However, it is also possible for pyruvate to be carboxylated by pyruvate carboxylase to form " oxaloacetate ".
• It can also be converted into Acetyl CoA and fed into the TCA cycle by condensing with oxaloacetate to form citrate.
• However, in the presence of high levels of malate and NAD +, citrate can stimulate the production of oxaloacetate.