oxalyl meaning

• Oxalyl-CoA decarboxylase is hypothesized to be evolutionarily related to acetolactate synthase, a TPP-dependent enzyme responsible for the biosynthesis of branched chain amino acids in certain organisms.
• The pods can be eaten but like many members of the genus " Lathyrus " they contain �-oxalyl-" L "-�, �-diaminopropionic acid, which can cause paralysis called lathyrism.
• Despite their similarities, only oxalyl-CoA decarboxylase is necessary for the formation of ATP in " Oxalobacter formigenes ", and exogenous ADP has been demonstrated to increase the decarboxylase activity of OXC, but not acetolactate synthase.
• No FAD binding is observed in oxalyl-CoA decarboxylase, but an excess of coenzyme A in the crystal structure has led to the hypothesis that the binding site was co-opted during OXC evolution to bind the CoA moiety of its substrate.
• While long and medium chain fatty acids are oxidized mainly in the mitochondria, DFAs are oxidized primarily in peroxisomes, which degrade DFAs completely to malonyl-CoA ( in the case of odd chain length DFAs ) and oxalyl-CoA ( for even chain length DFAs ).
• It can be synthesized by reacting 2-carbopentoxy-3, 5, 6-trichlorophenol with oxalyl chloride . ( Note : This article originally was called Bis ( 2, 4, 5-trichlorophenyl-6-carbopentoxyphenyl ) oxalate, but the subsequently added picture and formula have only two phenyl groups.
• Oxalyl-CoA decarboxylase is extremely important for the elimination of ingested oxalates found in human foodstuffs like coffee, tea, and chocolate, and the ingestion of such foods in the absence of " Oxalobacter formigenes " in the gut can result in kidney disease or even death as a result of oxalate poisoning.
• :: : " At about the same time, chemist Michael M . Rauhut was manager of exploratory research at American Cyanamid in Stamford, Conn . He and his colleagues corresponded with Chandross about his oxalyl chloride chemistry, then went to work on the reaction-- studying it and looking for avenues that would produce chemical light intense enough to be of practical use.
• Recently it has been found that a high-energy intermediate in one of these reactions ( between oxalyl chloride and hydrogen peroxide in ethyl acetate ), which is presumed to be 1, 2-dioxetanedione, can accumulate in solution at room temperature ( up to a few micromoles at least ), provided that the activating dye and all traces of metals and other reducing agents are removed from the system, and the reactions are carried out in an inert atmosphere.
• This carbon center ionizes to form a carbanion, which adds to the carbonyl group of oxalyl-CoA . This addition is followed by the decarboxylation of oxalyl-CoA, and then the oxidation and removal of formyl-CoA to regenerate the carbanion form of TPP . While the reaction mechanism is shared with other TPP-dependent enzymes, the residues found in the active site of OXC are unique, which has raised questions about whether TDP must be deprotonated by a basic amino acid at a second site away from the carbanion-forming site to activate the cofactor.