trypanothione in a sentence

1. It is an NADPH-dependent flavoenzyme that reduces trypanothione disulfide.
2. Trypanothione-dependent enzymes include reductases, peroxidases, glyoxalases and transferases.
3. A major function of trypanothione is in the defence against oxidative stress.
4. In parasitic kinetoplastids trypanothione synthase activity is key to survival.
5. Trypanothione-dependent hydrogen peroxide metabolism is particularly important in these organisms because they lack catalase.
6. It's difficult to find trypanothione in a sentence.
7. An antioxidant, trypanothione, defends the parasite against attacks from oxygen by converting it to water.
8. Mel Ox reacts with trypanothione ( a spermidine-glutathione adduct that replaces glutathione in trypanosomes ).
9. Ganem and Karplus have been focusing their drug-designing efforts on a parasitic enzyme, trypanothione reductase.
10. In these organisms, glutathione reduction is performed by either the thioredoxin or the trypanothione system, respectively.
11. The enzyme, trypanothione reductase, then promptly rearms the antioxidant, enabling it to resume its protective role.
12. In 1985, Alan Fairlamb discovered a unique thiol compound present in these parasites, and named it trypanothione.
13. The methylglyoxal reacts spontaneously with reduced glutathione ( or its equivalent, trypanothione ), ) forming a hemithioacetal.
14. Due to the need for trypanothione in order to defend against oxidative stresses, and maintain thiol and ribonucleotide metabolism.
15. Targeting trypanothione synthase could be a novel way of preventing and curing these diseases through disruption of the parasites'metabolism.
16. Studies on the effect of drugs on trypanothione metabolism resulted in the discovery that fexinidzole is a potential oral treatment for visceral leishmaniasis.
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