enalaprilat in a sentence

1. Enalaprilat was developed partly to overcome these limitations of captopril.
2. Enalaprilat, however, had a problem of its own.
3. Thus, enalaprilat was only suitable for intravenous administration.
4. This was overcome by the esterification of enalaprilat with ethanol to produce enalapril.
5. Peak plasma enalaprilat concentrations occur 2 to 4 hours after oral enalapril administration.
6. It's difficult to find enalaprilat in a sentence.
7. Enalaprilat, however, had a problem of its own in that it had poor oral availability.
8. This was overcome by the researchers at Merck by the esterification of enalaprilat with ethanol to produce enalapril.
9. Scientists at Merck created lisinopril by systematically altering each structural unit of enalaprilat, substituting various amino acids.
10. As a prodrug, enalapril is metabolized " in vivo " to the active form enalaprilat by various esterases.
11. Renal impairment [ particularly creatinine clearance < 20 ml / min ( < 1.2 L / h ) ] results in significant accumulation of enalaprilat and necessitates dosage reduction.