tumor suppressor genes meaning
[Medicine]
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost,a barrier to normal proliferation is removed and unregulated growth is possible.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost,a barrier to normal proliferation is removed and unregulated growth is possible.
Examples
More: Next- preliminary study on transformation of tumor suppressor gene p53 into tomato
- tumor suppressor gene
- 8p22 of human chromosome is an region rich in disease-related genes and is also the susceptible loci of oncogenes and tumor suppressor genes
- although inactivation of some tumor suppressor genes such as p53 and p16ink4a has been identified, no known oncogene is commonly activated in hepatocellular carcinomas
- This is one of more than 50 known tumor suppressor genes.
