monoclonal gammopathy meaning
[Medicine]
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells,usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.n : any of various disorders marked by proliferation of a single clone of antibody-producing lymphoid cells resulting in an abnormal increase of a monoclonal antibody in the blood serum and urine and that include both benign or asymptomatic conditions and neoplastic conditions (as multiple myeloma and Waldenström's macroglobulinemia) —see M PROTEIN 2
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells,usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.n : any of various disorders marked by proliferation of a single clone of antibody-producing lymphoid cells resulting in an abnormal increase of a monoclonal antibody in the blood serum and urine and that include both benign or asymptomatic conditions and neoplastic conditions (as multiple myeloma and Waldenström's macroglobulinemia) —see M PROTEIN 2
Examples
More: Next- Multiple myeloma or monoclonal gammopathy of undetermined significance can also cause the condition.
- "Plasma cell dyscrasia " is sometimes considered synonymous with paraproteinemia or monoclonal gammopathy.
- This can occur due to monoclonal gammopathies such as multiple myeloma and after intravenous immunoglobulin has been given.
- Chronic hives and a monoclonal gammopathy have been proposed as the major criteria, while the others represent minor criteria.
- Abnormal bands ( spikes ) are seen in monoclonal gammopathy of undetermined significance and multiple myeloma, and are useful in the diagnosis of these conditions.
