metastasis suppressor genes meaning
[Medicine]
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost,a barrier to normal proliferation is removed and unregulated growth is possible.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost,a barrier to normal proliferation is removed and unregulated growth is possible.
Examples
- expression of metastasis suppressor gene nm23-h1 in colorectal carcinoma and its relationship with clinical pathological parameters
- He is best known for his discovery of 4 of the 24 known metastasis suppressor genes.
- Kisspeptin is encoded by the metastasis suppressor gene KISS1, which is expressed in a variety of endocrine and gonadal tissues.
- Chromosomes 1, 6, 7, 8, 10, 11, 12, 16 and 17 harbor metastasis suppressor genes.
