lymphocyte activating factor meaning
A soluble factor produced by monocytes,macrophages,and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. IL-1 consists of two distinct forms,IL-1 alpha and IL-1 beta which perform the same functions but are distinct proteins. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation. The factor is distinct from INTERLEUKIN-2.
- The name " interleukin " was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 ( lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and " Heidikine " ) and interleukin 2 ( TSF, etc . ).