lck kinase meaning

  "lck kinase" in a sentence
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4,CD8 and the beta-chain of the IL-2 receptor,and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.


  1. Close proximity between the TCR complex and CD4 in this situation means the Lck kinase bound to the cytoplasmic tail of CD4 is able to tyrosine-phosphorylate the Immunoreceptor tyrosine activation motifs ( ITAM ) present on the cytoplasmic domains of CD3.

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