l type calcium channels meaning
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1,alpha-2,beta,gamma,and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
- the mrna expression of l type calcium channel in t-tubular membrane may increase due to the compensation for its functional decrease
- When a higher heart rate occurs, for example due to adrenergic stimulation, the L Type Calcium channel has increased activity.