cell cycle regulatory proteins meaning
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes,including CYCLIN-DEPENDENT KINASES,mitogen-activated kinases,CYCLINS,and phosphoprotein phosphatases (PHOSPHOPROTEIN PHOSPHATASE) as well as their putative substrates such as chromatin-associated proteins,CYTOSKELETAL PROTEINS,and TRANSCRIPTION FACTORS.
- The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle ( supplied by OMIM ).
- Wee1 protein is a tyrosine kinase that normally phosphorylates the Cdc2 cell cycle regulatory protein ( the homolog of CDK1 in humans ), a cyclin-dependent kinase, on a tyrosine residue.