cell cycle proteins meaning
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes,including CYCLIN-DEPENDENT KINASES,mitogen-activated kinases,CYCLINS,and phosphoprotein phosphatases (PHOSPHOPROTEIN PHOSPHATASE) as well as their putative substrates such as chromatin-associated proteins,CYTOSKELETAL PROTEINS,and TRANSCRIPTION FACTORS.
- Apoptosis is mediated through disrupting the regulated degradation of pro-growth cell cycle proteins.
- IKK-� has also been reported to regulate the cell cycle protein cyclin D1 in an NF-�B-independent manner.
- For adenovirus replication to occur, the host cell must be induced into S-phase by viral proteins interfering with cell cycle proteins.
- When the kinase activity of mTOR is activated, its downstream effectors, the synthesis of cell cycle proteins such as cyclin D and hypoxia-inducible factor-1a ( VEGF . Whether or not mTOR kinase is activated, determines whether the tumor cell produces key proteins needed for proliferation, growth, survival, and angiogenesis.