autosomal recessive juvenile parkinsonism meaning

A group of disorders which feature impaired motor control characterized by bradykinesia,MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE),secondary parkinsonism (see PARKINSON DISEASE,SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.


  1. Years earlier, the neurology clinic at Robert Wood Johnson Medical School ( RWJMS ) had located a family of Italian origin that encompassed at least five generations of more than 400 individuals and at least 60 members with PD, and traced their ancestors to the small village of parkin gene in autosomal recessive juvenile parkinsonism were discovered in 1998 and finally, between 2002-2005, DJ-1 gene mutations, PINK1 gene mutations and the most common mutations in the LRRK2 gene were identified in Japanese and European families.

Related Words

  1. autosomal recessive disease meaning
  2. autosomal recessive familial dystonia meaning
  3. autosomal recessive familial parkinson disease meaning
  4. autosomal recessive hereditary spastic paraplegia meaning
  5. autosomal recessive juvenile parkinson disease meaning
  6. autosomal recessive nemaline myopathy meaning
  7. autosomal recessive parkinsonism meaning
  8. autosomal recessive polycystic kidney meaning
  9. autosomal recessive polycystic kidney disease meaning
  10. autosomal recessive,hereditary spastic paraplegia meaning
PC Version