- Any of various red antibiotics isolated from soil bacteria
Derived forms: actinomycins
Type of: antibiotic, antibiotic drug
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription),with chain elongation more sensitive than initiation,termination,or release. As a result of impaired mRNA production,protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual,1993,p2015) n : any of various red or yellow-red mostly toxic polypeptide antibiotics isolated from soil bacteria (esp. Streptomyces antibioticus); specif : one used to inhibit DNA or RNA synthesis
- actinomycin d: [Medicine]A compou ...
- Actinomycin is a complex molecule that intercalates DNA and prevents RNA synthesis.
- The systematic name of this enzyme class is "'actinomycin lactonohydrolase " '.
- Actinomycin-D is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis.
- Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D ( 7-AAD ), are used as stains in microscopy and flow cytometry applications.
- Animal studies have shown actinomycin-D is corrosive to skin, irritating to the eyes and mucous membranes of the respiratory tract and highly toxic by the oral route.