actinomycin d meaning

  "actinomycin d" in a sentence
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription),with chain elongation more sensitive than initiation,termination,or release. As a result of impaired mRNA production,protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual,1993,p2015)n : DACTINOMYCIN
  • actinomycin:    Noun: actinomycinA ...
  • 'd:     /d/ short form of ...
  • a-d:    [Finance]Advance-D ...


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  1. Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D ( 7-AAD ), are used as stains in microscopy and flow cytometry applications.
  2. Viral RdRPs were discovered in the early 1960s from studies on mengovirus and polio virus when it was observed that these viruses were not sensitive to actinomycin D, a drug that inhibits cellular DNA-directed RNA synthesis.
  3. At present, treatment with single-agent methotrexate is recommended for low-risk disease, while intense combination regimens including EMACO ( etoposide, methotrexate, actinomycin D, cyclosphosphamide and vincristine ( Oncovin ) are recommended for intermediate or high-risk disease.
  4. The whole of replication occurs within the host cell cytoplasm and infection can even happen in cells that do not contain a nucleus ( known as enucleated cells ) and those treated with actinomycin D ( this antibiotic would inhibit viral replication if this occurred in the nucleus .)
  5. ""'Streptomyces parvus " "'is a bacterium species from the genus of " Streptomyces " which has been isolated from garden soil . " Streptomyces parvus " produces the actinomycin C complex, arylomycin A5, arylomycin A6 and actinomycin D.

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