actinomycin d meaning
[Medicine]
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription),with chain elongation more sensitive than initiation,termination,or release. As a result of impaired mRNA production,protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual,1993,p2015)n : DACTINOMYCIN
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription),with chain elongation more sensitive than initiation,termination,or release. As a result of impaired mRNA production,protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual,1993,p2015)n : DACTINOMYCIN
- actinomycin: Noun: actinomycinA ...
- 'd: /d/ short form of ...
- a-d: [Finance]Advance-D ...
Examples
More: Next- Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D ( 7-AAD ), are used as stains in microscopy and flow cytometry applications.
- Viral RdRPs were discovered in the early 1960s from studies on mengovirus and polio virus when it was observed that these viruses were not sensitive to actinomycin D, a drug that inhibits cellular DNA-directed RNA synthesis.
- At present, treatment with single-agent methotrexate is recommended for low-risk disease, while intense combination regimens including EMACO ( etoposide, methotrexate, actinomycin D, cyclosphosphamide and vincristine ( Oncovin ) are recommended for intermediate or high-risk disease.
- The whole of replication occurs within the host cell cytoplasm and infection can even happen in cells that do not contain a nucleus ( known as enucleated cells ) and those treated with actinomycin D ( this antibiotic would inhibit viral replication if this occurred in the nucleus .)
- ""'Streptomyces parvus " "'is a bacterium species from the genus of " Streptomyces " which has been isolated from garden soil . " Streptomyces parvus " produces the actinomycin C complex, arylomycin A5, arylomycin A6 and actinomycin D.
