tissue plasminogen activator meaning

  "tissue plasminogen activator" in a sentence
Noun: tissue plasminogen activator
  1. A thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction
    - Activase

Derived forms: tissue plasminogen activators

Type of: clot buster, thrombolytic, thrombolytic agent

Encyclopedia: Tissue plasminogen activator

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to PLASMIN. It has fibrin-binding activity and is immunologically different from URINARY PLASMINOGEN ACTIVATOR. The primary sequence,composed of 527 amino acids,is identical in both the naturally occurring and synthetic proteases. EC : a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack —abbr. TPA


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  1. the mechanism of the regulation of calcium to the expression of tissue plasminogen activator in epidermis
  2. Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator.
  3. Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator.
  4. However, the use of recombinant tissue plasminogen activator is not without risks.
  5. TPA, or tissue plasminogen activator, is the only federally approved drug treatment.

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