tissue plasminogen activator meaning
Noun: tissue plasminogen activator
- A thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction
Derived forms: tissue plasminogen activators
Encyclopedia: Tissue plasminogen activator
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to PLASMIN. It has fibrin-binding activity and is immunologically different from URINARY PLASMINOGEN ACTIVATOR. The primary sequence,composed of 527 amino acids,is identical in both the naturally occurring and synthetic proteases. EC 220.127.116.11.n : a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack
- the mechanism of the regulation of calcium to the expression of tissue plasminogen activator in epidermis
- Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator.
- Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator.
- However, the use of recombinant tissue plasminogen activator is not without risks.
- TPA, or tissue plasminogen activator, is the only federally approved drug treatment.