cd4 receptors meaning
55-kD Glycoproteins originally defined as differentiation antigens on T-lymphocytes,but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (Major Histocompatibility Complex) Class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as HIV receptors,binding directly to the envelope protein gp120 on HIV.
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- Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research.
- Viral entry into CD4-positive cells commences when three subunits of a glycoprotein 120 ( gp120 ) bind to CD4 receptor and a coreceptor.
- The real target, it seems, is the chemokine receptor, but to decoy the immune system the virus first latches on to the CD4 receptor.
- "HIV-1 can enter the microglial cell via CD4 receptors and chemokine co-receptors such as CCR3, CCR5, and CXCR4, with CCR5 being the most important of these.
- Additionally, in collaboration with Genentech, Tolerx is developing a modified version of TRX1, a humanized monoclonal antibody that binds to the CD4 receptor found on both T effector and T regulatory cells.