×

cd4 receptors meaning

  "cd4 receptors" in a sentence
  • [Medicine]
    55-kD Glycoproteins originally defined as differentiation antigens on T-lymphocytes,but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (Major Histocompatibility Complex) Class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as HIV receptors,binding directly to the envelope protein gp120 on HIV.

Examples

    More:   Prev    Next
  1. Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research.
  2. Viral entry into CD4-positive cells commences when three subunits of a glycoprotein 120 ( gp120 ) bind to CD4 receptor and a coreceptor.
  3. The real target, it seems, is the chemokine receptor, but to decoy the immune system the virus first latches on to the CD4 receptor.
  4. "HIV-1 can enter the microglial cell via CD4 receptors and chemokine co-receptors such as CCR3, CCR5, and CXCR4, with CCR5 being the most important of these.
  5. Additionally, in collaboration with Genentech, Tolerx is developing a modified version of TRX1, a humanized monoclonal antibody that binds to the CD4 receptor found on both T effector and T regulatory cells.

Related Words

  1. cd4 immunoadhesins meaning
  2. cd4 lymphocyte count meaning
  3. cd4 lymphocyte counts meaning
  4. cd4 molecule meaning
  5. cd4 positive t lymphocytes meaning
  6. cd4 t cell meaning
  7. cd4+ cell count meaning
  8. cd4+ cell counts meaning
  9. cd4+ count meaning
  10. cd4+ counts meaning
PC Version